Cancer-associated fibroblasts drive glycolysis in a targetable signaling loop implicated in head and neck squamous cell carcinoma progression

Despite aggressive therapies, head and neck squamous cell carcinoma (HNSCC) is associated with a less than 50% 5-year survival rate. Late stage HNSCC frequently consists of up to 80% cancer-associated fibroblasts (CAF). We previously reported that CAF-secreted hepatocyte growth factor (HGF) facilita...

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Publicado no:Cancer Res
Main Authors: Kumar, Dhruv, New, Jacob, Vishwakarma, Vikalp, Joshi, Radhika, Enders, Jonathan, Lin, Fangchen, Dasari, Sumana, Gutierrez, Wade R, Leef, George, Ponnurangam, Sivapriya, Chavan, Hemantkumar, Ganaden, Lydia, Thornton, Mackenzie M., Dai, Hongying, Tawfik, Ossama, Straub, Jeffrey, Shnayder, Yelizaveta, Kakarala, Kiran, Tsue, Terance Ted, Girod, Douglas A., Van Houten, Bennett, Anant, Shrikant, Krishnamurthy, Partha, Thomas, Sufi Mary
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050074/
https://ncbi.nlm.nih.gov/pubmed/29769197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1076
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