De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance

Overexpression and/or gene amplification of HER2, a crucial member of the HER family of four receptors, occur in about 15–20% of breast cancers and define an aggressive subtype of the disease. Activated HER homo and heterodimers govern a complex and redundant downstream signaling network that regula...

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Veröffentlicht in:Breast
Hauptverfasser: Veeraraghavan, Jamunarani, De Angelis, Carmine, Reis-Filho, Jorge S., Prat, Aleix, Rimawi, Mothaffar F., Pascual, Tomás, Osborne, C. Kent, Schiff, Rachel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6050048/
https://ncbi.nlm.nih.gov/pubmed/28687441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.breast.2017.06.022
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