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De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance
Overexpression and/or gene amplification of HER2, a crucial member of the HER family of four receptors, occur in about 15–20% of breast cancers and define an aggressive subtype of the disease. Activated HER homo and heterodimers govern a complex and redundant downstream signaling network that regula...
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| Publicado no: | Breast |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6050048/ https://ncbi.nlm.nih.gov/pubmed/28687441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.breast.2017.06.022 |
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