Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

The recent identification of compounds that interact with the spliceosome (sudemycins, spliceostatin A, and meayamycin) indicates that these molecules modulate aberrant splicing via SF3B1 inhibition. Through whole transcriptome sequencing, we have demonstrated that treatment of Rh18 cells with sudem...

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Vydáno v:RNA
Hlavní autoři: Wu, Gang, Fan, Liying, Edmonson, Michael N., Shaw, Timothy, Boggs, Kristy, Easton, John, Rusch, Michael C., Webb, Thomas R., Zhang, Jinghui, Potter, Philip M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049506/
https://ncbi.nlm.nih.gov/pubmed/29844105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.065383.117
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