Diacylglycerol kinase ζ (DGKζ) and Casitas b-lineage proto-oncogene b–deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance

Targeting negative regulators downstream of the T cell receptor (TCR) represents a novel strategy to improve cancer immunotherapy. Two proteins that serve as critical inhibitory regulators downstream of the TCR are diacylglycerol kinase ζ (DGKζ), a regulator of Ras and PKC-θ signaling, and Casitas b...

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Bibliographische Detailangaben
Veröffentlicht in:Immunohorizons
Hauptverfasser: Wesley, Erin M., Xin, Gang, McAllister, Donna, Malarkannan, Subramaniam, Newman, Debra K., Dwinell, Michael B., Cui, Weiguo, Johnson, Bryon D., Riese, Matthew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048965/
https://ncbi.nlm.nih.gov/pubmed/30027154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/immunohorizons.1700055
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