An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE

BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG)-reactive T-helper (Th)1 cells induce conventional experimental autoimmune encephalomyelitis (cEAE), characterized by ascending paralysis and monocyte-predominant spinal cord infiltrates, in C57BL/6 wildtype (WT) hosts. The same T cells induce an...

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Udgivet i:J Neuroinflammation
Main Authors: Stoolman, Joshua S., Duncker, Patrick C., Huber, Amanda K., Giles, David A., Washnock-Schmid, Jesse M., Soulika, Athena M., Segal, Benjamin M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048869/
https://ncbi.nlm.nih.gov/pubmed/30012158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1237-y
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