Concurrent somatic KRAS mutation and germline 10q22.3-q23.2 deletion in a patient with juvenile myelomonocytic leukemia, developmental delay, and multiple malformations: a case report

BACKGROUND: The proto-oncogene KRAS performs an essential function in normal tissue signaling, and the mutation of KRAS gene is a key step in the development of many cancers. Somatic KRAS mutations are often detected in patients with solid and non-solid tumors, whereas germline KRAS mutations are im...

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Vydáno v:BMC Med Genomics
Hlavní autoři: Yao, Ruen, Yu, Tingting, Xu, Yufei, Li, Guoqiang, Yin, Lei, Zhou, Yunfang, Wang, Jian, Yan, Zhilong
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Case Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048798/
https://ncbi.nlm.nih.gov/pubmed/30012129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-018-0377-3
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