AKT isoform-specific expression and activation across cancer lineages

BACKGROUND: Aberrant AKT activation is prevalent across human cancer lineages, providing an important therapeutic target. AKT comprises three isoforms that mediate critical non-redundant, even opposing functions in cancer pathophysiology. Therefore, targeting specific AKT isoforms in particular canc...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Wang, Jue, Zhao, Wei, Guo, Huifang, Fang, Yong, Stockman, Sarah Elizabeth, Bai, Shanshan, Ng, Patrick Kwok-Shing, Li, Yang, Yu, Qinghua, Lu, Yiling, Jeong, Kang Jin, Chen, Xiaohua, Gao, Meng, Liang, Jiyong, Li, Wentao, Tian, Xingsong, Jonasch, Eric, Mills, Gordon B., Ding, Zhiyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048698/
https://ncbi.nlm.nih.gov/pubmed/30012111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4654-5
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