Targeting β1-integrin inhibits vascular leakage in endotoxemia

Loss of endothelial integrity promotes capillary leakage in numerous diseases, including sepsis, but there are no effective therapies for preserving endothelial barrier function. Angiopoietin-2 (ANGPT2) is a context-dependent regulator of vascular leakage that signals via both endothelial TEK recept...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hakanpaa, Laura, Kiss, Elina A., Jacquemet, Guillaume, Miinalainen, Ilkka, Lerche, Martina, Guzmán, Camilo, Mervaala, Eero, Eklund, Lauri, Ivaska, Johanna, Saharinen, Pipsa
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048499/
https://ncbi.nlm.nih.gov/pubmed/29941602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722317115
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