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Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH
Endosomes have emerged as a central hub and pathogenic driver of Alzheimer’s disease (AD). The earliest brain cytopathology in neurodegeneration, occurring decades before amyloid plaques and cognitive decline, is an expansion in the size and number of endosomal compartments. The strongest genetic ri...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6048470/ https://ncbi.nlm.nih.gov/pubmed/29946028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801612115 |
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