Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration

CD133, a widely known marker of cancer stem cells, was recently found in extracellular vesicles. However, the mechanisms underlying CD133 translocation to the extracellular space remain largely unknown. Here we report that CD133 is monoubiquitinated. Ubiquitination occurs primarily on complex glycos...

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Publicat a:Mol Cell Biol
Autors principals: Yang, Fan, Xing, Yang, Li, Yinan, Chen, Xiaoning, Jiang, Jianhai, Ai, Zhilong, Wei, Yuanyan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048314/
https://ncbi.nlm.nih.gov/pubmed/29760280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00024-18
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