Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration

CD133, a widely known marker of cancer stem cells, was recently found in extracellular vesicles. However, the mechanisms underlying CD133 translocation to the extracellular space remain largely unknown. Here we report that CD133 is monoubiquitinated. Ubiquitination occurs primarily on complex glycos...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Cell Biol
Main Authors: Yang, Fan, Xing, Yang, Li, Yinan, Chen, Xiaoning, Jiang, Jianhai, Ai, Zhilong, Wei, Yuanyan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048314/
https://ncbi.nlm.nih.gov/pubmed/29760280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00024-18
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