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The Impairment of TorsinA's Binding to and Interactions With Its Activator: An Atomistic Molecular Dynamics Study of Primary Dystonia

Primary dystonia's prolonged muscle contractions and the associated abnormal postures and twisting movements remain incurable. Genetic mutation/deletion of GAG from TorsonA's gene resulting in ΔE303 (which weakens the binding between TorsinA and its activator, such as LULL1) primarily caus...

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書目詳細資料
發表在:Front Mol Biosci
主要作者: Salawu, Emmanuel O.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048259/
https://ncbi.nlm.nih.gov/pubmed/30042949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2018.00064
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