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Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment

Enhancement of hematopoietic stem cell (HSC) homing and engraftment is clinically critical, especially for cord blood (CB) hematopoietic cell transplantation. Here we report that specific HDAC5 inhibition highly upregulates CXCR4 surface expression in human CB HSCs and progenitor cells (HPCs). This...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Huang, Xinxin, Guo, Bin, Liu, Sheng, Wan, Jun, Broxmeyer, Hal E.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048146/
https://ncbi.nlm.nih.gov/pubmed/30013077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05178-5
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