High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer

BACKGROUND: Matrix metalloproteinase-8 (MMP-8) is a protease mainly expressed by neutrophils that cleaves numerous substrates, including collagens and cytokines. We have previously shown that serum MMP-8 levels increase in colorectal cancer (CRC) and correlate with distant metastasis. However, short...

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Détails bibliographiques
Publié dans:Br J Cancer
Auteurs principaux: Sirniö, Päivi, Tuomisto, Anne, Tervahartiala, Taina, Sorsa, Timo, Klintrup, Kai, Karhu, Toni, Herzig, Karl-Heinz, Mäkelä, Jyrki, Karttunen, Tuomo J., Salo, Tuula, Mäkinen, Markus J., Väyrynen, Juha P.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048114/
https://ncbi.nlm.nih.gov/pubmed/29808017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0136-4
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