Concomitant attenuation of HMG-CoA reductase expression potentiates the cancer cell growth-inhibitory effect of statins and expands their efficacy in tumor cells with epithelial characteristics

HMG-CoA reductase (HMGCR) inhibitors, statins, are potent cholesterol reducing drugs that exhibit anti-tumor effects in vitro and in animal models, including attenuation of metastasis formation, and their use correlates with reduced cancer-specific mortality in retrospective human cohort studies. Ho...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Ishikawa, Takuro, Hosaka, Yoshinao Z., Beckwitt, Colin, Wells, Alan, Oltvai, Zoltán N., Warita, Katsuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047681/
https://ncbi.nlm.nih.gov/pubmed/30034619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25448
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