Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

BACKGROUND: Endoplasmic reticulum stress is associated with podocyte apoptosis in the pathogenesis of diabetic nephropathy (DN). A previous study has demonstrated that emodin has a protective effect in the kidney by suppressing proliferation of mesangial cells and inhibiting the renal tubular epithe...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Tian, Nianxiu, Gao, Yanbin, Wang, Xiaolei, Wu, Xiaoming, Zou, Dawei, Zhu, Zhiyao, Han, ZheJi, Wang, Tao, Shi, Yimin
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2018
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047613/
https://ncbi.nlm.nih.gov/pubmed/30034224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S167405
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