S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice

Elevated plasma total homocysteine (tHcy) is associated with a number of human diseases including coronary artery disease, stroke, osteoporosis and dementia. It is highly correlated with intracellular S-adenosylhomocysteine (SAH). Since SAH is a strong inhibitor of methyl-transfer reactions involvin...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab Rep
Main Authors: Lee, Hyung-Ok, Wang, Liqun, Kuo, Yin-Ming, Andrews, Andrew J., Gupta, Sapna, Kruger, Warren D.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047060/
https://ncbi.nlm.nih.gov/pubmed/30023284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgmr.2018.01.002
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