Evaluation of a Janus kinase 1 inhibitor, PF‐04965842, in healthy subjects: A phase 1, randomized, placebo‐controlled, dose‐escalation study

AIMS: To determine the safety, tolerability, pharmacokinetics and pharmacodynamics of the Janus kinase 1‐selective inhibitor, PF‐04965842. METHODS: This was a phase 1, first‐in‐human, randomized, double‐blind, placebo‐controlled, combination single‐ and multiple‐dose escalation, parallel design stud...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Peeva, Elena, Hodge, Martin R., Kieras, Elizabeth, Vazquez, Michael L., Goteti, Kosalaram, Tarabar, Sanela G., Alvey, Christine W., Banfield, Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046510/
https://ncbi.nlm.nih.gov/pubmed/29672897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13612
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