Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats

BACKGROUND: Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and aut...

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Vydáno v:Mediators Inflamm
Hlavní autoři: Han, Wen, Wang, Hao, Su, Longxiang, Long, Yun, Cui, Na, Liu, Dawei
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046132/
https://ncbi.nlm.nih.gov/pubmed/30050390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/4798209
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