Preclinical evaluation of the kappa-opioid receptor antagonist CERC-501 as a candidate therapeutic for alcohol use disorders

Prior work suggests a role of kappa-opioid signaling in the control of alcohol drinking, in particular when drinking is escalated due to alcohol-induced long-term neuroadaptations. Here, we examined the small molecule selective kappa antagonist CERC-501 in rat models of alcohol-related behaviors, wi...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Domi, E, Barbier, E, Augier, E, Augier, G, Gehlert, D, Barchiesi, R, Thorsell, A, Holm, L, Heilig, M
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046052/
https://ncbi.nlm.nih.gov/pubmed/29463912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0015-y
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