Influence of alcoholism and cholesterol on TSPO binding in brain: PET [(11)C]PBR28 studies in humans and rodents

Neuroinflammation appears to contribute to neurotoxicity observed with heavy alcohol consumption. To assess whether chronic alcohol results in neuroinflammation we used PET and [(11)C]PBR28, a ligand that binds to the 18-kDa translocator protein (TSPO), to compare participants with an alcohol use di...

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Udgivet i:Neuropsychopharmacology
Main Authors: Kim, Sung Won, Wiers, Corinde E., Tyler, Ryan, Shokri-Kojori, Ehsan, Jang, Yeon Joo, Zehra, Amna, Freeman, Clara, Ramirez, Veronica, Lindgren, Elsa, Miller, Gregg, Cabrera, Elizabeth A., Stodden, Tyler, Guo, Min, Demiral, Şükrü B., Diazgranados, Nancy, Park, Luke, Liow, Jeih-San, Pike, Victor, Morse, Cheryl, Vendruscolo, Leandro F., Innis, Robert B., Koob, George F., Tomasi, Dardo, Wang, Gene-Jack, Volkow, Nora D.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046047/
https://ncbi.nlm.nih.gov/pubmed/29777199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0085-x
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