(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice

(R,S)-Ketamine has rapid and sustained antidepressant effects in depressed patients. Although the metabolism of (R,S)-ketamine to (2 R,6 R)-hydroxynorketamine (HNK), a metabolite of (R)-ketamine, has been reported to be essential for its antidepressant effects, recent evidence suggests otherwise. Th...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Yamaguchi, Jun-ichi, Toki, Hidetoh, Qu, Youge, Yang, Chun, Koike, Hiroyuki, Hashimoto, Kenji, Mizuno-Yasuhira, Akiko, Chaki, Shigeyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046044/
https://ncbi.nlm.nih.gov/pubmed/29802366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0084-y
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