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(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice
(R,S)-Ketamine has rapid and sustained antidepressant effects in depressed patients. Although the metabolism of (R,S)-ketamine to (2 R,6 R)-hydroxynorketamine (HNK), a metabolite of (R)-ketamine, has been reported to be essential for its antidepressant effects, recent evidence suggests otherwise. Th...
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| Izdano u: | Neuropsychopharmacology |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer International Publishing
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6046044/ https://ncbi.nlm.nih.gov/pubmed/29802366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0084-y |
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