CART cells are prone to Fas- and DR5-mediated cell death

Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that CART cells progressively upregulate Fas, FasL...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Tschumi, Benjamin O., Dumauthioz, Nina, Marti, Bastien, Zhang, Lianjun, Schneider, Pascal, Mach, Jean-Pierre, Romero, Pedro, Donda, Alena
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Short Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045821/
https://ncbi.nlm.nih.gov/pubmed/30005714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-018-0385-z
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