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CART cells are prone to Fas- and DR5-mediated cell death
Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that CART cells progressively upregulate Fas, FasL...
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| Pubblicato in: | J Immunother Cancer |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6045821/ https://ncbi.nlm.nih.gov/pubmed/30005714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-018-0385-z |
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