Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis

Myocardial infarction (MI) is a major cause of death in Western countries and finding new strategies for its prevention and treatment is thus of high priority. In a previous study, we have demonstrated a pathophysiologic relevance for the heterophilic interaction of CCL5 and CXCL4 in the progression...

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Udgivet i:Sci Rep
Main Authors: Vajen, Tanja, Koenen, Rory R., Werner, Isabella, Staudt, Mareike, Projahn, Delia, Curaj, Adelina, Sönmez, Tolga Taha, Simsekyilmaz, Sakine, Schumacher, David, Möllmann, Julia, Hackeng, Tilman M., Hundelshausen, Philipp von, Weber, Christian, Liehn, Elisa A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045661/
https://ncbi.nlm.nih.gov/pubmed/30006564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29026-0
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