Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103(+)CD39(+) tumor-infiltrating CD8 T cells (CD8 TIL) are enriched for tumor-reactive cells both in primary and metastatic tumors. This CD8...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Duhen, Thomas, Duhen, Rebekka, Montler, Ryan, Moses, Jake, Moudgil, Tarsem, de Miranda, Noel F., Goodall, Cheri P., Blair, Tiffany C., Fox, Bernard A., McDermott, Jason E., Chang, Shu-Ching, Grunkemeier, Gary, Leidner, Rom, Bell, Richard Bryan, Weinberg, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045647/
https://ncbi.nlm.nih.gov/pubmed/30006565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05072-0
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