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X-ray-Structure-Based Identification of Compounds with Activity against Targets from Different Families and Generation of Templates for Multitarget Ligand Design

[Image: see text] Compounds with multitarget activity (promiscuity) are increasingly sought in drug discovery. However, promiscuous compounds are often viewed controversially in light of potential assay artifacts that may give rise to false-positive activity annotations. We have reasoned that the st...

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Bibliografiske detaljer
Udgivet i:ACS Omega
Main Authors: Gilberg, Erik, Stumpfe, Dagmar, Bajorath, Jürgen
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045467/
https://ncbi.nlm.nih.gov/pubmed/30023769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b01849
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