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Role of Cys(I)–Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors
[Image: see text] α-Conotoxins preferentially antagonize muscle and neuronal nicotinic acetylcholine receptors (nAChRs). Native α-conotoxins have two disulfide links, C(I)–C(III) and C(II)–C(IV), and owing to the inherent properties of disulfide bonds, α-conotoxins have been systematically engineere...
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| Publicado no: | ACS Omega |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2017
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6044955/ https://ncbi.nlm.nih.gov/pubmed/30023726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00639 |
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