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Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors
[Image: see text] We have recently identified a new class of filamenting temperature-sensitive mutant Z (FtsZ)-interacting compounds that possess a 2,4,6-trisubstituted pyrimidine–quinuclidine scaffold with moderate antibacterial activity. Employing this scaffold as a molecular template, a compound...
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| 發表在: | ACS Omega |
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| Main Authors: | , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical Society
2017
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6044853/ https://ncbi.nlm.nih.gov/pubmed/30023544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00701 |
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