Efficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors

[Image: see text] We have recently identified a new class of filamenting temperature-sensitive mutant Z (FtsZ)-interacting compounds that possess a 2,4,6-trisubstituted pyrimidine–quinuclidine scaffold with moderate antibacterial activity. Employing this scaffold as a molecular template, a compound...

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Bibliographic Details
Published in:ACS Omega
Main Authors: Chan, Kin-Fai, Sun, Ning, Yan, Siu-Cheong, Wong, Iris L. K., Lui, Hok-Kiu, Cheung, Kwan-Choi, Yuan, Jian, Chan, Fung-Yi, Zheng, Zhiwei, Chan, Edward W. C., Chen, Sheng, Leung, Yun-Chung, Chan, Tak Hang, Wong, Kwok-Yin
Format: Artigo
Language:Inglês
Published: American Chemical Society 2017
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044853/
https://ncbi.nlm.nih.gov/pubmed/30023544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00701
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