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Empirical Valence Bond Simulations Suggest a Direct Hydride Transfer Mechanism for Human Diamine Oxidase

[Image: see text] Diamine oxidase (DAO) is an enzyme involved in the regulation of cell proliferation and the immune response. This enzyme performs oxidative deamination in the catabolism of biogenic amines, including, among others, histamine, putrescine, spermidine, and spermine. The mechanistic de...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Maršavelski, Aleksandra, Petrović, Dušan, Bauer, Paul, Vianello, Robert, Kamerlin, Shina Caroline Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044848/
https://ncbi.nlm.nih.gov/pubmed/30023875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00346
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