Discovery of Retinoic Acid-Related Orphan Receptor γt Inverse Agonists via Docking and Negative Image-Based Screening

[Image: see text] Retinoic acid-related orphan receptor γt (RORγt) has a vital role in the differentiation of T-helper 17 (TH17) cells. Potent and specific RORγt inverse agonists are sought for treating TH17-related diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes. Here, the aim...

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Publicat a:ACS Omega
Autors principals: Rauhamäki, Sanna, Postila, Pekka A., Lätti, Sakari, Niinivehmas, Sanna, Multamäki, Elina, Liedl, Klaus R., Pentikäinen, Olli T.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2018
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044741/
https://ncbi.nlm.nih.gov/pubmed/30023945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00603
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