Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells

[Image: see text] A combined biochemical, structural, and cell biology characterization of dictyostatin is described, which enables an improved understanding of the structural determinants responsible for the high-affinity binding of this anticancer agent to the taxane site in microtubules (MTs). Th...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Trigili, Chiara, Barasoain, Isabel, Sánchez-Murcia, Pedro A., Bargsten, Katja, Redondo-Horcajo, Mariano, Nogales, Aurora, Gardner, Nicola M., Meyer, Arndt, Naylor, Guy J., Gómez-Rubio, Elena, Gago, Federico, Steinmetz, Michel O., Paterson, Ian, Prota, Andrea E., Díaz, J. Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044705/
https://ncbi.nlm.nih.gov/pubmed/30023505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.6b00317
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