Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma

TP63 encodes TAp63, which is functionally similar to the tumor suppressor TP53, and ΔNp63, which lacks the transcription-activating domain of TAp63 and appears potently oncogenic in squamous cell carcinomas (SCCs). In this study, we developed an integrated CRISPR interference (CRISPRi) system to sel...

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Vydáno v:Oncotarget
Hlavní autoři: Yoshida, Masakazu, Yokota, Etsuko, Sakuma, Tetsushi, Yamatsuji, Tomoki, Takigawa, Nagio, Ushijima, Toshikazu, Yamamoto, Takashi, Fukazawa, Takuya, Naomoto, Yoshio
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6044376/
https://ncbi.nlm.nih.gov/pubmed/30018747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25678
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