Nrf2 Is a Central Regulator of Metabolic Reprogramming of Myeloid-Derived Suppressor Cells in Steady State and Sepsis

Arising in inflammatory conditions, myeloid-derived suppressor cells (MDSCs) are constantly confronted with intracellular and extracellular reactive oxygen species molecules and oxidative stress. Generating mice with a constitutive activation of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) we...

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Pubblicato in:Front Immunol
Autori principali: Ohl, Kim, Fragoulis, Athanassios, Klemm, Patricia, Baumeister, Julian, Klock, Wiebke, Verjans, Eva, Böll, Svenja, Möllmann, Julia, Lehrke, Michael, Costa, Ivan, Denecke, Bernd, Schippers, Angela, Roth, Johannes, Wagner, Norbert, Wruck, Christoph, Tenbrock, Klaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6043652/
https://ncbi.nlm.nih.gov/pubmed/30034396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01552
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