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Network-based approach to prediction and population-based validation of in silico drug repurposing
Here we identify hundreds of new drug-disease associations for over 900 FDA-approved drugs by quantifying the network proximity of disease genes and drug targets in the human (protein–protein) interactome. We select four network-predicted associations to test their causal relationship using large he...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6043492/ https://ncbi.nlm.nih.gov/pubmed/30002366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05116-5 |
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