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Efficacy and mechanism of antitumor activity of an antibody targeting transferrin receptor 1 (TfR1) in mouse models of human multiple myeloma()
The transferrin receptor 1 (TfR1) is an attractive target for antibody-mediated cancer therapy. We previously developed a mouse/human chimeric IgG3 antibody (ch128.1) targeting human TfR1, which exhibits direct in vitro cytotoxicity against certain human malignant B cells through TfR1 degradation an...
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| Pubblicato in: | J Immunol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6042853/ https://ncbi.nlm.nih.gov/pubmed/29654211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700787 |
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