A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass

Leptin expression decreases after fat loss and is increased when obesity develops, and its proper quantitative regulation is essential for the homeostatic control of fat mass. We previously reported that a distant leptin enhancer 1 (LE1), 16 kb upstream from the transcription start site (TSS), confe...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhang, Yinxin, Dallner, Olof Stefan, Nakadai, Tomoyoshi, Fayzikhodjaeva, Gulya, Lu, Yi-Hsueh, Lazar, Mitchell A., Roeder, Robert G., Friedman, Jeffrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6042069/
https://ncbi.nlm.nih.gov/pubmed/29891714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806366115
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