Metabolic Disposition of Luteolin Is Mediated by the Interplay of UDP-Glucuronosyltransferases and Catechol-O-Methyltransferases in Rats

Luteolin partially exerts its biologic effects via its metabolites catalyzed by UDP-glucuronosyltransferases (UGTs) and catechol-O-methyltransferases (COMTs). However, the interplay of UGTs and COMTs in mediating luteolin disposition has not been well clarified. In this study, we investigated the gl...

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Gepubliceerd in:Drug Metab Dispos
Hoofdauteurs: Wang, Liping, Chen, Qingwei, Zhu, Lijun, Li, Qiang, Zeng, Xuejun, Lu, Linlin, Hu, Ming, Wang, Xinchun, Liu, Zhongqiu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041822/
https://ncbi.nlm.nih.gov/pubmed/28031430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.073619
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