Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation

HIV-1 protease (PR) is a homodimeric enzyme that is autocatalytically cleaved from the Gag-Pol precursor. Known PR inhibitors bind the mature enzyme several orders of magnitude more strongly than the PR precursor. Inhibition of PR at the precursor level, however, may stop the process at its rate-lim...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Humpolíčková, Jana, Weber, Jan, Starková, Jana, Mašínová, Eva, Günterová, Jana, Flaisigová, Iva, Konvalinka, Jan, Majerová, Taťána
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041310/
https://ncbi.nlm.nih.gov/pubmed/29992979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28638-w
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