A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity

ZIC2 mutation is known to cause holoprosencephaly (HPE). A subset of ZIC2 HPE probands harbour cardiovascular and visceral anomalies suggestive of laterality defects. 3D-imaging of novel mouse Zic2 mutants uncovers, in addition to HPE, laterality defects in lungs, heart, vasculature and viscera. A s...

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Publicado no:Sci Rep
Main Authors: Dykes, Iain M., Szumska, Dorota, Kuncheria, Linta, Puliyadi, Rathi, Chen, Chiann-mun, Papanayotou, Costis, Lockstone, Helen, Dubourg, Christèle, David, Véronique, Schneider, Jurgen E., Keane, Thomas M., Adams, David J., Brown, Steve D. M., Mercier, Sandra, Odent, Sylvie, Collignon, Jérôme, Bhattacharya, Shoumo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041270/
https://ncbi.nlm.nih.gov/pubmed/29992973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28714-1
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