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Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe

Mitochondria dynamically alter their subcellular localization during cell movement, although the underlying mechanisms remain largely elusive. The small GTPase Arf6 and its signaling pathway involving AMAP1 promote cell invasion via integrin recycling. Here we show that the Arf6–AMAP1 pathway promot...

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Vydáno v:Nat Commun
Hlavní autoři: Onodera, Yasuhito, Nam, Jin-Min, Horikawa, Mei, Shirato, Hiroki, Sabe, Hisataka
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041267/
https://ncbi.nlm.nih.gov/pubmed/29992963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05087-7
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