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Tetrahydrobiopterin treatment reduces brain L-Phe but only partially improves serotonin in hyperphenylalaninemic ENU1/2 mice
Hyperphenylalaninemia (HPA) caused by hepatic phenylalanine hydroxylase (PAH) deficiency has severe consequences on brain monoamine neurotransmitter metabolism. We have studied monoamine neurotransmitter status and the effect of tetrahydrobiopterin (BH(4)) treatment in Pah(enu1/enu2) (ENU1/2) mice,...
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| Publicado no: | J Inherit Metab Dis |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6041158/ https://ncbi.nlm.nih.gov/pubmed/29520738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-018-0150-y |
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