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High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU)

Central nervous system (CNS) deficiencies of the monoamine neurotransmitters, dopamine and serotonin, have been implicated in the pathophysiology of neuropsychiatric dysfunction in phenylketonuria (PKU). Increased brain phenylalanine concentration likely competitively inhibits the activities of tyro...

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Detalhes bibliográficos
Publicado no:Mol Genet Metab
Main Authors: Winn, Shelley R, Scherer, Tanya, Thöny, Beat, Harding, Cary O
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706464/
https://ncbi.nlm.nih.gov/pubmed/26653793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2015.11.012
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