Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors

Free fatty acid receptor 2 (FFAR2, also named GPR43), is activated by short-chain fatty acids (SCFAs), such as butyrate, that are produced when gut bacteria ferment dietary fiber. FFAR2 has been suggested to regulate colonic inflammation, which is a major risk factor for the development of colon can...

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Vydáno v:Int J Cancer
Hlavní autoři: Pan, Pan, Oshima, Kiyoko, Huang, Yi-Wen, Agle, Kimberle A., Drobyski, William R., Chen, Xiao, Zhang, Jianying, Yearsley, Martha M., Yu, Jianhua, Wang, Li-Shu
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041131/
https://ncbi.nlm.nih.gov/pubmed/29524208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31366
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