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Efficient targeted integration into the bovine Rosa26 locus using TALENs
The genetic modification of cattle has many agricultural and biomedical applications. However, random integration often results in the unstable expression of transgenes and unpredictable phenotypes. Targeting genes to the “safe locus” and stably expressing foreign genes at a high level are desirable...
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| Published in: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6039519/ https://ncbi.nlm.nih.gov/pubmed/29991797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28502-x |
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