Production of hypoallergenic milk from DNA-free beta-lactoglobulin (BLG) gene knockout cow using zinc-finger nucleases mRNA

The whey protein β-lactoglobulin (BLG) is a major milk allergen which is absent in human milk. Here, we for the first time generated DNA-free BLG bi-allelic knockout cow by zinc-finger nuclease (ZFNs) mRNA and produced BLG-free milk. According to the allergenicity evaluation of BLG-free milk, we fou...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Sun, Zhaolin, Wang, Ming, Han, Shiwen, Ma, Shuangyu, Zou, Zhiyuan, Ding, Fangrong, Li, Xinrui, Li, Ling, Tang, Bo, Wang, Haiping, Li, Ning, Che, Huilian, Dai, Yunping
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194018/
https://ncbi.nlm.nih.gov/pubmed/30337546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32024-x
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