Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences

OBJECTIVE—: The mechanisms underlying the cardiovascular benefit of the anti-diabetic drug metformin are poorly understood. Recent studies have suggested metformin may upregulate macrophage reverse cholesterol transport. The final steps of reverse cholesterol transport are mediated by the sterol tra...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Molusky, Matthew M., Hsieh, Joanne, Lee, Samuel X., Ramakrishnan, Rajasekhar, Tascau, Liana, Haeusler, Rebecca A., Accili, Domenico, Tall, Alan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2018
Témata:
Basic Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039406/
https://ncbi.nlm.nih.gov/pubmed/29853564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.311212
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