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Naturally occurring Missense MRGPRX2 variants display Loss of Function Phenotype for Mast Cell Degranulation in response to Substance P, Hemokinin-1, Human β-defensin 3 and Icatibant
Human mast cells (MCs) express a novel G protein-coupled receptor (GPCR), known as Mas-related G protein coupled receptor X2 (MRGPRX2). Activation of this receptor by a diverse group of cationic ligands such as neuropeptides (NPs), host defense peptides (HDPs) and FDA-approved drugs contributes to c...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6039248/ https://ncbi.nlm.nih.gov/pubmed/29794017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701793 |
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