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Exacerbated S. aureus foot infections in obese/diabetic mice are associated with impaired germinal center reactions, Ig class-switching, and humoral immunity

Obese, type 2 diabetics (T2D) are at an increased risk of foot infection with impaired immune function believed to be a critical factor in the infectious process. Here we test the hypothesis that humoral immune defects contribute to exacerbated foot infection in a murine model of obesity/T2D. C57BL/...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Farnsworth, Christopher W, Schott, Eric M, Benvie, Abigail, Kates, Stephen L, Schwarz, Edward M., Gill, Steven R, Zuscik, Michael J, Mooney, Robert A
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039240/
https://ncbi.nlm.nih.gov/pubmed/29858265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800253
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