P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-promoting Myofibroblasts

BACKGROUND & AIMS: Hepatic stellate cells (HSCs) contribute to desmoplasia and stiffness of liver metastases by differentiating into matrix-producing myofibroblasts. We investigated whether stiffness due to the presence of tumors increases activation of HSCs into myofibroblasts and their tumor-p...

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Publicado no:Gastroenterology
Main Authors: Dou, Changwei, Liu, Zhikui, Tu, Kangsheng, Zhang, Hongbin, Chen, Chen, Yaqoob, Usman, Wang, Yuanguo, Wen, Jialing, van Deursen, Jan, Sicard, Delphine, Tschumperlin, Daniel, Zou, Hongzhi, Huang, Wei-Chien, Urrutia, Raul, Shah, Vijay H., Kang, Ningling
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039101/
https://ncbi.nlm.nih.gov/pubmed/29454793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.02.015
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